One-pot synthesis of 1,4-disubstituted 1,2,3-triazoles from nitrobenzenes

A facile synthesis of 1,4-disubstituted 1,2,3-triazoles was achieved from nitrobenzenes and terminal alkynes under mild conditions. The reactions were successful for nitrobenzenes and terminal alkynes bearing various functionalities, from which the 1,2,3-triazole derivatives were smoothly synthesized through a four-step one-pot sequence.

Graphical abstractA facile synthesis of 1,4-disubstituted 1,2,3-triazoles was achieved from nitrobenzenes and terminal alkynes in moderate to excellent yields under mild conditions. The reactions were successful for nitrobenzenes and terminal alkynes bearing functionalities, from which the 1,2,3-triazole derivatives were smoothly synthesized through a four-step one-pot sequence.Figure optionsDownload full-size imageDownload as PowerPoint slide