Synthesis and biological activities of some fluorine- and piperazine-containing 1,2,4-triazole thione derivatives

A series of fluorine- and piperazine-containing 1,2,4-triazole thione derivatives were synthesized by the Mannich reaction of triazole intermediates with various substituted piperazines and formaldehyde in high yields. Structures of title compounds were confirmed by melting points, IR, 1H NMR, 13C NMR and elemental analysis. The preliminary bioassays for 17 novel title compounds showed that several compounds have significant fungicidal activity against Cercospora arachidicola, Physalospora piricola and Rhizoctonia cerealis at 50 μg/mL.

Graphical abstractA series of novel fluorine- and piperazine-containing 1,2,4-triazole thione derivatives were synthesized by the Mannich reaction of triazole intermediate in high yields. Their herbicidal and fungicidal activities were evaluated.Figure optionsDownload full-size imageDownload as PowerPoint slide