Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1254617 | Chinese Chemical Letters | 2014 | 5 Pages |
A novel fused isocoumarin skeleton has been synthesized through selective domino multicyclizations by mixing homothallic acid and 2,3-diphenylacryloyl chloride at 200 °C under catalyst and solvent free reaction conditions. Six fused rings with two stereogenic centers were assembled in a convenient one-pot operation in good yield. The resulting hexacyclic fused isocoumarin skeleton and its stereochemistry was fully characterized and unambiguously confirmed by X-ray diffraction analysis.
Graphical abstractIsocoumarins are important synthetic targets due to their diverse biological applications. A simple, cheap and convenient one-pot method to construct novel isocoumarin framework with six fused rings and two stereogenic centers is described.Figure optionsDownload full-size imageDownload as PowerPoint slide