A simple synthetic approach for the transformation of (S)-Ugi's amine

A simple synthetic approach for the transformation of (S)-Ugi's amine, another configuration of (R)-Ugi's amine, one of the most widely used intermediate in the preparation of chiral ferrocene-based ligands, has been developed via esterification using anhydride, alkaline hydrolysis and active manganese dioxide oxidation, and the corresponding ferrocenyl ketone was afforded in good yields.

Graphical abstractA simple synthetic approach for the transformation of (S)-Ugi's amine has been developed via esterification using anhydride, alkaline hydrolysis and active manganese dioxide oxidation, and to afford the corresponding ferrocenyl ketone in good yields.Figure optionsDownload full-size imageDownload as PowerPoint slide