| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1254631 | Chinese Chemical Letters | 2012 | 4 Pages |
Abstract
In order to find novel antibacterial agents with superior antibacterial activity and overcoming multidrug resistance, a series of pleuromutilin derivatives with novel C(14) side chain were synthesized and evaluated for their in vitro antibacterial activities. The results of antibacterial acticities indicated that most of the derivatives showed potent activities against Gram-positive organisms. In particular, compound 10d exhibited the most potent inhibitory activity compared with pleuromutilin and linezoid, emerged as potential molecule for further investigation.
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Authors
Li Qiang Fu, Chen Yu Ling, Xing Sheng Guo, Hui Li He, Yu She Yang,