Synthesis of N-arylquinolone derivatives bearing 2-thiophenoxyquinolines and their antimicrobial evaluation

A new series of 2-thiophenoxyquinolines based trifluoromethyl substituted N-aryl quinolone derivatives 8a–f and 9a–f have been synthesized via a one-pot multicomponent reaction. In vitro antimicrobial activity of the synthesized compounds was investigated against a representative panel of pathogenic strains. Compounds 8c, 9c and 9e exhibited comparable antimicrobial activity to first line drugs.

Graphical abstractA new series of N-arylquinolone derivatives bearing 2-thiophenoxyquinolines have been synthesized by a base-catalyzed cyclocondensation reaction through the multi-component reaction (MCR) approach. All the synthesized compounds were investigated against three Gram-positive, three Gram-negative bacteria and two fungi using the broth microdilution MIC (minimum inhibitory concentration) method for their in vitro antimicrobial activity.Figure optionsDownload full-size imageDownload as PowerPoint slide