Microwave irradiation: Novel and facile methods for the synthesis of new pyrimidinones

We describe here a rapid process for the preparation of new 9-chloromethyl-12-aryl-10,12-dihydrobenzo[5,6]chromeno[2,3-d]pyrimidin-11-ones 5a-d and 10-chloromethyl-7-aryl-7,9-dihydrobenzo[7,8]chromeno[2,3-d]pyrimidin-8-ones 6a-d by two different methods utilizing microwave irradiation. This methodology provides better yields (72%–80%) and high purity of the title compounds.

Graphical abstractA synthesis of new pyrimidinones by two different methods utilizing microwave (MW) irradiation is described.Figure optionsDownload full-size imageDownload as PowerPoint slide