An eco-friendly water mediated synthesis of 1,2,3-triazolyl-2-aminopyrimidine hybrids as highly potent anti-bacterial agents

An elegant and efficient synthesis of novel 1,2,3-triazole fused 2-aminopyrimidine hybrids has been accomplished for the first time in the green solvent viz. water. The hybrid molecules exhibit significant anti-bacterial activity when screened against three human pathogens viz. Staphylococcus aureus, Pseudomonas aeruginosa and Klebsiella pneumoniae. In comparison to the commercially marketed drug tetracycline, some of them are equally potent and a few are more potent.

Graphical abstractAn elegant green synthesis of 1,2,3-triazolyl linked 2-aminopyrimidine hybrids in water has been accomplished for the first time. Their antibacterial activities are comparable with that of tetracycline.Figure optionsDownload full-size imageDownload as PowerPoint slide