An H-phosphonate strategy for the synthesis of 2′,3′-dideoxynucleoside triphosphates and homodinucleotides

The triphosphates and homodinucleotides of AZT and d4T have been efficiently synthesized from the corresponding nucleoside 5′-H-phosphonate monoesters via the reactive pyridinium phosphoramidate intermediates.

Graphical abstractAn H-phosphonate approach for the synthesis of 2′,3′-dideoxynucleoside triphosphates and homodinucleotides has been established.Figure optionsDownload full-size imageDownload as PowerPoint slide