One-pot and novel route for the synthesis of 4-substituted-1,2,4-triazolidine-3,5-diones

The efficient and one-pot synthesis of 4-substituted-1,2,4-triazolidin-3,5-dione derivatives (4-substituted urazoles) via combination of triphosgene, substituted anilines, and ethyl carbazate in the presence of cesium carbonate is presented.

Graphical abstractDifferent types of 4-substituted-1,2,4-triazolidin-3,5-diones have been prepared via combination of substituted anilines, triphosgene, and ethyl carbazate in the presence of cesium carbonate with moderate to good yields.Figure optionsDownload full-size imageDownload as PowerPoint slide