Novel one-pot synthesis of 4H-chromene derivatives using amino functionalized silica gel catalyst

A simple, efficient, and environmentally benign method for the synthesis of 4H-chromene derivatives was developed using well ordered and recoverable amino functionalized silica gel as a base catalyst. The 4H-chromene derivatives were obtained in short time and excellent yield (87%–96%) by three component reaction of aldehydes, malononitrile and cyclic 1,3-diketones in water at 70 °C.

Graphical abstractA simple, efficient, and environmentally benign method for the synthesis of 4H-chromene derivatives was developed using well ordered and recoverable amino functionalized silica gel as a base catalyst. The 4H-chromene derivatives were obtained in short time and excellent yield (87%–96%) by three component reaction of aldehydes, malononitrile and cyclic 1,3-diketones in water at 70 °C.Figure optionsDownload full-size imageDownload as PowerPoint slide