Three new eudesmane sesquiterpenes from Artemisia vestita

Three eudesmane sesquiterpene lactones, namely artemivestinolides A–C (1–3), along with three known 11-epimeric lactones (4–6), were isolated from the aerial parts of Artemisia vestita. Their structures were elucidated on the basis of extensive spectroscopic analyses (IR, HR-ESIMS, 1D NMR and 2D NMR), and the absolute configurations were determined by single-crystal X-ray diffraction (with copper radiation). Furthermore, in an in vitro assay, the three new compounds exhibited a moderate inhibition of the lipopolysaccharide (LPS)-induced nitric oxide (NO) production in BV-2 microglial cells.

Graphical abstractThree new eudesmane sesquiterpene lactones, namely artemivestinolides A–C (1–3), along with three known 11-epimeric lactones (4–6), were isolated from the aerial parts of Artemisia vestita. An in vitro assay showed that these new compounds exhibited a moderate inhibition of the lipopolysaccharide (LPS)-induced nitric oxide (NO) production in BV-2 microglial cells.Figure optionsDownload full-size imageDownload as PowerPoint slide