Article ID Journal Published Year Pages File Type
1254902 Chinese Chemical Letters 2013 5 Pages PDF
Abstract

An environmentally benign aqueous protocol for the synthesis of 3,4-dihydropyrimidin-2-(1H)-ones and thiones promoted by a green catalyst, silica gel-supported l-pyrrolidine-2-carboxylic acid-4-hydrogen sulfate, has been developed. The use of nontoxic, thermally stable and inexpensive amino acid catalyst makes the process simple with minimal amount of chemical waste. Compared with classical Biginelli reaction conditions, this new method has the advantages of high yields and simple workup procedures.

Graphical abstractSilica gel-supported l-pyrrolidine-2-carboxylic acid-4-hydrogen sulfate as a green organocatalyst has been introduced for the synthesis of 3,4-dihydropyrimidin-2-(1H)-ones and thiones.Figure optionsDownload full-size imageDownload as PowerPoint slide

Related Topics
Physical Sciences and Engineering Chemistry Chemistry (General)
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