| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1254912 | Chinese Chemical Letters | 2013 | 4 Pages |
The present work reports the first solid phase synthesis of biologically interesting d-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (d-threo-PDMP) derivatives. This synthetic strategy includes facile preparation of versatile azido intermediate (5) in a relatively short sequence and the subsequent derivatization of 5, which led to a series of sulfonamide, urea and heterocycle substituted PDMP analogs (10 and 10′). With this method, a 5280-member compound library has been successfully built by IRORI Nanokan© system.
Graphical abstractA solid phase method for the synthesis of PDMP analogs has been developed. With this synthetic strategy, a 5280-member library of PDMP derivatives has been successfully built.Figure optionsDownload full-size imageDownload as PowerPoint slide
