Direct N-gem-difluorocyclopropylation of nitro-heterocycles by utilizing gem-difluorocyclopropyl tosylate

We have developed an efficient method to achieve N-gem-difluorocyclopropylation of N-heterocycles with the use of gem-difluorocyclopropyl tosylate as a building block under mild conditions. gem-Difluorocyclopropyl tosylates could be easily prepared on a large scale and exhibit great stability.

Graphical abstractN-gem-Difluorocyclopropylation of N-heterocycles with the use of gem-difluorocyclopropyl tosylate as building block under mild conditions was described. gem-Difluorocyclopropyl tosylates could be easily prepared on a large scale and exhibit great stability.Figure optionsDownload full-size imageDownload as PowerPoint slide