Synthesis and bioactivity of novel strobilurin derivatives containing the pyrrolidine-2,4-dione moiety

(E)-Methyl-2-(2-(bromomethyl)phenyl)-3-methoxyacrylate was reacted with substituted 1-acetylpyrrolidine-2,4-diones and 3-(1-(hydroxylamino)ethylidene)pyrrolidine-2,4-diones respectively to synthesize two series of β-methoxyacrylate derivatives containing the pyrrolidine-2,4-dione moiety. The structures of the targeted compounds were confirmed by IR, 1H NMR, 13C NMR, MS and elemental analysis. The fungicidal activity against Rhizoctonia solani, Botrytis cinerea and Fusarium graminearum was evaluated. The bioassay results demonstrated that these compounds showed visible fungicidal activity.

Graphical abstractTwo series of β-methoxyacrylate derivatives containing the pyrrolidine-2,4-dione moiety were synthesized. These compounds showed visible fungicidal activity against phytopathogenic fungi.Figure optionsDownload full-size imageDownload as PowerPoint slide