| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1254983 | Chinese Chemical Letters | 2014 | 4 Pages |
A series of mono l-amino acid ester, mono non-steroid anti-inflammation drug (NSAID), carboxylic ester derivatives of acyclonucleoside phosphonates were prepared by using a “one pot synthesis” method and their in vitro anti-HBV activity were evaluated in HepG 2.2.15 cells. Compound 9a exhibited more potent anti-HBV activity and lower cytotoxicity than those of adefovir dipivoxil with IC50 and selective index (SI) values of 0.48 μmol/L and 763.72, respectively.
Graphical abstractA series of mono l-amino acid ester, mono non-steroid anti-inflammation drug (NSAID) carboxylic ester derivatives of acyclonucleoside phosphonates were synthesized and their in vitro anti-HBV activity were evaluated in HepG 2.2.15 cells. Compound 9a exhibit more potent antiviral activity and lower cytotoxicity than adefovir dipivoxil with IC50 and selective index (SI) values of 0.48 μmol/L and 763.72, respectively.Figure optionsDownload full-size imageDownload as PowerPoint slide
