One-pot synthesis of novel pyrrolo-1,4-benzoxazines via a three-component reaction of 2-amino phenols, acetylenic esters and nitrostyrene derivatives

A simple and efficient synthetic protocol has been developed using a one-pot, three-component reaction involving 2-amino phenols, dialkyl acetylene dicarboxylates and nitrostyrene derivatives. Utilizing this protocol, a variety of novel pyrrolo-1,4-benzoxazine derivatives were synthesized in excellent yields.

Graphical abstractA variety of novel pyrrolo-1,4-benzoxazine derivatives were synthesized using a one-pot, three-component reaction involving 2-amino phenols, dialkyl acetylene dicarboxylates and nitrostyrene derivatives.Figure optionsDownload full-size imageDownload as PowerPoint slide