Synthesis and acaricidal activity of strobilurin-pyrimidine derivatives

Pyriminostrobin, a new acaricide, was discovered in our previous studies. Because introducing fluorine into organic compounds can increase bioactivity, pyriminostrobin was modified as a series of strobilurin-pyrimidine derivatives for biological screening. The compounds were characterized by 1H NMR, MS and elemental analysis. Preliminary bioassays demonstrated that compounds 7e and 7i exhibited significant control against Tetranychus cinnabarinus (Boisd.) at 0.625 mg L−1, and their acaricidal potencies were higher than pyriminostrobin in a greenhouse. The relationship between structure and acaricidal activity was also studied.

Graphical abstractBased on the concept of introducing fluorine into pyriminostrobin to improve its bio-activity, a series of strobilurin-pyrimidine derivatives were synthesized for biological screening. Two highly active compounds 7e and 7i were discovered with significant controlling of Tetranychus cinnabarinus (Boisd.) at 0.625 mg L−1.Figure optionsDownload full-size imageDownload as PowerPoint slide