Synthesis of 2,5-disubstitued benzimidazole using SnCl2-catalyzed reduction system at room temperature

Stannous chloride dihydrate is used as an efficient catalyst in reductive cyclization of 2-nitro-5-substituted aniline Schiff base leading to stable 2,5-disubstitued benzimidazole derivatives in excellent yields with good purity. It provides a novel method of synthesis of 2,5-disubstitued benzimidazole under reductive system at room temperature.

Graphical abstractIt provides a novel method of synthesis of 2,5-disubstitued benzimidazole derivatives at room temperature in excellent yields with good purity using stannous chloride dehydrate as an efficient catalyst in the reductive cyclization of 2-nitro-5-substituted aniline Schiff base.Figure optionsDownload full-size imageDownload as PowerPoint slide