Sodium fluoride as an efficient catalyst for the synthesis of 2,4-disubstituted-1,3-thiazoles and selenazoles at ambient temperature

Sodium fluoride was found to be a simple, mild and efficient catalyst for the synthesis of 2,4-disubstituted 1,3-thiazoles and selenazoles utilizing phenacyl bromides/3-(2-bromoacetyl)-2H-chromen-2-one and thiourea/phenylthiourea/selenourea in aqueous methanol at ambient temperature. Analytically pure products are formed within 1–3 min in excellent yields.

Graphical abstractSodium fluoride was found to be a simple, mild and efficient catalyst for the synthesis of 2,4-disubstituted 1,3-thiazoles and selenazoles in aqueous methanol at ambient temperature.Figure optionsDownload full-size imageDownload as PowerPoint slide