Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1255032 | Chinese Chemical Letters | 2013 | 4 Pages |
A series of novel chiral C2-symmetric multidentate aminophosphine ligands have been successfully synthesized by Schiff-base condensation of bis(o-formylphenyl)phenylphosphane and easily available monoprotected (1R,2R)-diaminocyclohexane. The catalytic properties of these ligands were investigated in Ir-catalyzed asymmetric transfer hydrogenation of various aromatic ketones, giving the corresponding optical active alcohols with up to 98% conversion and good ee under mild reaction conditions.
Graphical abstractA series of novel chiral C2-symmetric multidentate aminophosphine ligands have been successfully synthesized by Schiff-base condensation of bis(o-formylphenyl)phenylphosphane and easily available monoprotected (1R,2R)-diaminocyclohexane. The catalytic properties of these ligands were investigated in Ir-catalyzed asymmetric transfer hydrogenation of various aromatic ketones, giving the corresponding optical active alcohols with up to 98% conversion and good ee under mild reaction conditions.Figure optionsDownload full-size imageDownload as PowerPoint slide