Distereoselective one-pot synthesis of pyrimidopyrimidines using sulfated tin oxide as a reusable catalyst: An extension of Biginelli-type reaction

The Biginelli-type compounds 4,5,8a-triarylhexahydropyrimido[4,5-d]pyrimidine-2,7(1H,3H)-diones were synthesized by a one-pot three-component reaction using sulfated tin oxide as a reusable catalyst. This method has the advantages of high yields, short reaction time, simple starting materials and reusability of catalyst for several times.

Graphical abstractThe Biginelli-type compounds 4,5,8a-triarylhexahydropyrimido[4,5-d]pyrimidine-2,7(1H,3H)-diones were synthesized by a one-pot three-component reaction using sulfated tin oxide as reusable as the catalyst. This method has the advantages of high yields, short reaction time, simple starting materials and reusability of catalyst for several times.Figure optionsDownload full-size imageDownload as PowerPoint slide