An efficient, rapid and facile procedure for conversion of aldoximes to nitriles using triphenylphosphine and N-halo sulfonamides

N,N,N′,N′-Tetrabromobenzene-1,3-disulfonamide (TBBDA)/triphenylphosphine and N,N,N′,N′-tetrachlorobenzene-1,3-disulfonamide (TCBDA)/triphenylphosphine have been introduced as highly efficient systems for the versatile conversion of aldoxime derivatives into nitriles. The process reported here is operationally simple and reactions have been mildly performed in dichloromethane at room temperature.

Graphical abstractTBBDA/triphenylphosphine and TCBDA/triphenylphosphine have been introduced as highly efficient systems for the conversion of aldoxime derivatives into nitriles.Figure optionsDownload full-size imageDownload as PowerPoint slide