| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1255153 | Chinese Chemical Letters | 2012 | 4 Pages |
Abstract
Novel farnesylthiosalicylic acid (FTA) derivatives 5a–m with different substituted 1,3,4-thiadiazoles were synthesized. Compounds 5b, 5c, 5e and 5f displayed anti-tumor activities superior to FTA in most cancer cells tested. Furthermore, 5e induced tumor cell apoptosis, which was accompanied by lower Bcl-2 expression, but with higher Bax and caspase 3 expression activities in cancer cells.
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Authors
Yong Ling, You An Xiao, Guang Tong Chen, Dong Geng Wang, Yu Qin Li, Xin Yang Wang, Heng Zheng,