| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1255280 | Chinese Chemical Letters | 2013 | 6 Pages |
Abstract
A series of neamine-heterocycle conjugates were designed and synthesized. All new compounds displayed more potent inhibitory effect on HIV replication than neamine, among them two compounds displayed stronger anti-HIV activity than neomycin B. The results suggested that it might be a promising approach to modify neamine for the discovery of new anti-HIV agents.
Graphical abstractSynthetic neamine-heterocycle conjugates showed potent inhibitory effect on HIV replication.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Chemistry (General)
Authors
Ri-Bai Yan, Yan-Fen Wu, Jun Liu, Xiao-Lian Zhang, Xin-Shan Ye,