Synthesis and bioactivities of some new 1H-pyrazole derivatives containing an aryl sulfonate moiety

A new series of 1H-pyrazole derivatives 5a–j bearing an aryl sulfonate moiety have been synthesized by a one-pot cyclo-condensation reaction of 2-(3-(dimethylamino)acryloyl)phenyl-4-methyl benzene sulfonates 4a–e and hydrazine hydrate or phenyl hydrazine in ethanol under reflux conditions. Some of the newly synthesized compounds were screened for their anti-inflammatory activity. All synthesized compounds were screened against Gram positive and Gram negative bacterial and fungal strains. The compound 5b was found to be a potent anti-inflammatory agent while the majority of the compounds were found to be active against microbial strains.

Graphical abstractA new series of 1H-pyrazole derivatives bearing an aryl sulfonate moiety has been synthesized by a one-pot cyclo-condensation reaction of 2-(3-(dimethylamino)acryloyl)phenyl-4-methylbenzene sulfonates and hydrazine hydrate or phenyl hydrazine in ethanol under reflux conditions. Some of the newly synthesized compounds were screened for anti-inflammatory and antimicrobial activity.Figure optionsDownload full-size imageDownload as PowerPoint slide