| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1255350 | Chinese Chemical Letters | 2012 | 4 Pages |
Abstract
An efficient and eco-friendly protocol for the chemoselective N-benzyloxycarbonylation of amines was described. The reaction of amines with benzyl chloroformate (Cbz-Cl) in the presence of PEG-600 at room temperature afforded the corresponding N-Cbz derivatives in excellent yields. The method is applicable to the N-Cbz protection of aliphatic (acyclic and cyclic) and aromatic amines.
Keywords
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Physical Sciences and Engineering
Chemistry
Chemistry (General)
Authors
Chun Lin Zhang, Dong Feng Zhang, Hong Yi Zhao, Zi Yun Lin, Hai Hong Huang,