Supported N-propylsulfamic acid on magnetic nanoparticles used as recoverable and recyclable catalyst for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones in water

An efficient and eco-friendly method is reported for the synthesis of 2-substituted-2,3-dihydroquinazolin-4(1H)-ones from direct cyclocondensation of anthranilamide with aldehydes and ketones using N-propylsulfamic acid supported onto magnetic Fe3O4 nanoparticles (MNPs-PSA) as a recoverable and recyclable nanocatalyst in good to excellent yields in water at 70 °C. The catalyst was readily separated using an external magnet and reusable without significant loss of their catalytic efficiency.

Graphical abstractMNPs-PSA was used as an interphase magnetically nanocatalyst for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones in water. The catalyst was easily recovered and reused for 10 times without any significant loss in catalytic activity.Figure optionsDownload full-size imageDownload as PowerPoint slide