| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1255389 | Chinese Chemical Letters | 2013 | 4 Pages |
The flavonoids as inhibitors of CYP1A1 exhibit chemopreventive effects against certain procarcinogens and have been considered as the promising cancer preventive agents. A series of novel 7,8-dimethoxy-α-naphthoflavones as the substrate analogs were designed and prepared. The enzyme assay suggested that all of these new flavones were stronger inhibitors of CYP1A1 than the lead compound α-naphthoflavone. Among the tested ones, 3h showed the most potent inhibitory effects.
Graphical abstractA series of new 7,8-dimethoxy-α-naphthoflavones were synthesized using 1,5-dihydroxynaphthalene as the starting material. These compounds exhibited potent inhibitory effects on recombined human CYP1A1 enzyme in vitro.Figure optionsDownload full-size imageDownload as PowerPoint slide
