| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1255420 | Chinese Chemical Letters | 2009 | 4 Pages |
Abstract
Two novel steroid-linked nitrogen mustard conjugates 1a and 1b were synthesized by using estrogenic acid 4 coupled with aniline mustard 8 and phenol mustard 13 in an esterification or amidation procedure. Preliminary cytotoxic screening on cancer cell lines in vitro showed that, the steroid-ester linked nitrogen mustard conjugate 1a exhibited obvious increasing of activities.
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Authors
Hua Bing Zhang, Ji Jun Xue, Xiao Long Zhao, De Gang Liu, Ying Li,