| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1255473 | Chinese Chemical Letters | 2011 | 4 Pages |
Abstract
Copolymers mPEG-PCL were prepared and grafted onto polyethylenimine (PEI) to synthesize copolymers mPEG-PCL-g-PEI with low cytotoxicity. The mPEG-PCL-g-PEI could condense siRNA to form nanoparticles with positive zeta potential. These nanoparticles could delivery siRNA into cells to effectively inhibit the expression of target gene, which suggested that mPEG-PCL-g-PEI could serve as a highly efficient vector for siRNA delivery.
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Authors
Wei Huang, Ming Lv, Zhong Gao Gao,