| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1255490 | Chinese Chemical Letters | 2013 | 4 Pages |
Abstract
In order to investigate the effects on the cytotoxicity of indole-3-oxalylamino podophyllotoxin analogs, seven novel podophyllotoxin derivatives were synthesized. The compounds were tested against Hela, K562 or K562/A02 cancer cells in vitro, four of which showed significant cytotoxicity. Among them 9a, 9b and 9c were superior to the positive control VP-16.
Graphical abstractBased on the medical chemistry combination principles, seven novel C4-N-substituted novel podophyllotoxin derivatives were synthesized. Among them, several analogs showed an improved anti-tumor activity than podophyllotoxin.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Chemistry (General)
Authors
Ting Ai, Shao-Yu Shi, Li-Ting Chen, Ling Li, Bo Cao, Ying Gao, Hong Chen, Jing Zhou,