| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1255523 | Chinese Chemical Letters | 2009 | 4 Pages |
Abstract
A series of novel nitric oxide-donating derivatives (7a-e, 8a-e) were synthesized by coupling furoxan and nitric oxide with irbesartan analogue and their cytotoxicity against BEL7402 cells in vitro were evaluated by MTT method. It was found that 8c exhibits the most cytotoxic activities with IC50 value of 12.5 μmol/L. The hybrids of AT1 antagonist and nitric oxide donor appear to have beneficial effects on antitumor.
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Physical Sciences and Engineering
Chemistry
Chemistry (General)
Authors
Yan Chun Zhang, Jin Pei Zhou, Xiao Ming Wu, Wei Hong Pan,