Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1255552 | Chinese Chemical Letters | 2011 | 4 Pages |
Abstract
Based on the active site of lanosterol 14α-demethylase of azole antifungal agents, sixteen 1-(1H-1,2,4-triazole-1-yl)- 2-(2,4-difluorophenyl)-3-(N-n-butyl-N-1-substitutedbenzyl-4-methylene-1H-1,2,3-triazole)-2-propanols have been designed, synthesized and evaluated as antifungal agents. Results of preliminary antifungal tests against eight human pathogenic fungi in vitro showed that some of the compounds exhibited excellent activities with broad spectrum.
Related Topics
Physical Sciences and Engineering
Chemistry
Chemistry (General)
Authors
Bao Gang Wang, Shi Chong Yu, Xiao Yun Chai, Yong Zheng Yan, Hong Gang Hu, Qiu Ye Wu,