Article ID Journal Published Year Pages File Type
1255583 Chinese Chemical Letters 2012 4 Pages PDF
Abstract

An efficient synthesis of hexahydropyrido[2,3-d]pyrimidinetrione derivatives is achieved via tandem Knoevenagel–Michael addition of aromatic aldehydes, methylcyanoacetate and 4(6)-aminouracil in solvent-free conditions in the presence of 10 mol% of ZrO2 nanoparticles (ZrO2 NPs) as a heterogenous catalyst. The procedure is formed in high yields, short reaction time and an environmentally friendly specificity.

Related Topics
Physical Sciences and Engineering Chemistry Chemistry (General)
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