Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1255583 | Chinese Chemical Letters | 2012 | 4 Pages |
Abstract
An efficient synthesis of hexahydropyrido[2,3-d]pyrimidinetrione derivatives is achieved via tandem Knoevenagel–Michael addition of aromatic aldehydes, methylcyanoacetate and 4(6)-aminouracil in solvent-free conditions in the presence of 10 mol% of ZrO2 nanoparticles (ZrO2 NPs) as a heterogenous catalyst. The procedure is formed in high yields, short reaction time and an environmentally friendly specificity.
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Authors
Shahrzad Abdolmohammadi, Maryam Afsharpour,