| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1255598 | Chinese Chemical Letters | 2012 | 4 Pages |
Abstract
A new isocoumarin, tenuissimasatin (1), was isolated from metabolites of the endophytic fungus Alternaria tenuissima (Nees & T. Nees: Fr.) Wiltshire, which was isolated from the bark of Erythrophleum fordii Oliver, together with 11 known compounds (2–12). The structure and absolute configuration of 1 was determined by means of NMR and CD analysis. Compound 3 shows selective cytotoxic activity on human colon cancer cell HCT-8 (IC50 = 1.78 μmol/L) by MTT test in vitro. Other compounds show no such activities (IC50 > 10 μmol/L).
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Physical Sciences and Engineering
Chemistry
Chemistry (General)
Authors
Zhen Feng Fang, Shi Shan Yu, Wan Qi Zhou, Xiao Guang Chen, Shuang Gang Ma, Yong Li, Jing Qu,