Palladium-catalyzed Suzuki–Miyaura cross-coupling reaction of organoboronic acids with N-protected 4-iodophenyl alanine linked isoxazoles

Suzuki–Miyaura coupling reaction of N-protected 4-iodopheyl alanine isoxazoles with arylboronic acids, catalyzed by palladium, efficiently produce benzyl-N-(4-bipheyl)-2-(3-methyl-5(E)-2-aryl-1-ethenyl-4- isoxazolyl)-amino-2-oxoethyl) carbamates in good yields. This process is first of its kind to construct carbon–carbon bond formation having biaryl motif on amino acid linked isoxazole moiety.