Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1255652 | Chinese Chemical Letters | 2011 | 4 Pages |
Abstract
Eight 16,17-pyrazo-annulated steroidal derivatives were synthesized and evaluated in vitro vascular endothelial growth factor (VEGF) inhibitory activity with 2-methoxyestradiol (2-ME) as the reference compound. Most of the compounds showed potent VEGF inhibitory activity with EC50 values of micromolar or submicromolar range. Among them, the compounds 3 and 8 exhibited similar EC50 values and obviously better TI values compared with 2-ME.
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Authors
Hong Shan Liu, Hu Ling Zheng, Mei Ge, Peng Xia, Ying Chen,