Synthesis of novel fullerene α-amino acid conjugates

Aspartic acid and glutamic acid with protected α-amino and α-carboxyl groups had been used to react with the activated hydroxyl group of N-substituted 3,4-fullero pyrrolidine. The products were deprotected, affording two monofullerene α-amino acids, monofullerene aspartic acid (mFas) and monofullerene glutamic acid (mFgu). Then a bifullerene glutamic acid conjugate (bFguC) was synthesized by reaction of mFgu containing protected amino group with N-substituted 3,4-fullero pyrrolidine.