Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1255804 | Chinese Chemical Letters | 2010 | 4 Pages |
Abstract
Vanadium-catalyzed oxidative kinetic resolution (OKR) of methyl o-chloromandelate 2a, key intermediate of the well-known oral antiplatelet agent (S)-clopidogrel, was achieved by ambient air for the first time. The air oxidation system, which was composed of vanadium and tridentate Schiff base ligands derived from amino alcohols and salicylaldehyde derivatives, afforded an efficient and economic approach to the target intermediate with high enantioselectivities (>99% ee).
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Chemistry
Chemistry (General)
Authors
Lu Yin, Xian Jia, Xing Shu Li, Albert S.C. Chan,