| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1255955 | Chinese Chemical Letters | 2010 | 4 Pages |
Abstract
A series of novel 4″-O-carbamoyl analogs of clarithromycin were synthesized and evaluated for their in vitro antibacterial activity. All of the desired compounds showed excellent activity against erythromycin-susceptible S. pneumoniae. Particularly, 4-fluorobenzyl carbamate 7a demonstrated potent activity against erythromycin-resistant S. pneumoniae encoded by the mef gene, and remarkably improved activity against erythromycin-resistant S. pneumoniae encoded by the erm gene, and the erm and mef genes.
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Authors
Xue Cui Shen, Bo Jiao, Shu Tao Ma,