| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1255959 | Chinese Chemical Letters | 2010 | 4 Pages |
Abstract
Simple organic nitrogen bases, such as Et3N, pyridine, DBU, etc., were found to be convenient and useful reagents for deprotection of TBDMS groups on acidic hydroxyl groups. The efficiency of these bases has an apparent order: 1° amine > 2° amine > 3° amine and aliphatic base > aromatic base. In aqueous DMSO and at room temperature, phenolic TBDMS ethers were removed selectively in the presence of alcoholic TBDMS ethers. And catalytic base can make these reactions complete. This method is high-yielding, fast, clean, safe and cost-effective.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Chemistry (General)
Authors
Jian Rong Zhu, Ji Jun Xue, Wen Ze Li, Xue Song Chen, Ying Li,