| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1255966 | Chinese Chemical Letters | 2010 | 4 Pages |
Abstract
A series of novel 7′-azaindirubin (1a–g) and 7-azaindirubin (2a, 2c, 2e and 2f) derivatives were designed and synthesized. Their structures were characterized by 1H NMR and MS spectroscopy as well as by elemental analysis. Their inhibitory properties against CDK2/cylinA were evaluated in vitro. In contrast to indirubin, some of the described azaindirubins emerged as potent inhibitors of CDK2/cylinA and compound 2b had more potent activity. Biological tests also showed that nitrogen atom at 7-position of azaindirubin was more beneficial to enhance the kinase inhibitory activity.
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Physical Sciences and Engineering
Chemistry
Chemistry (General)
Authors
Zhao Hui Wang, Ying Dong, Tao Wang, Ming Hong Shang, Wei Yi Hua, Qi Zheng Yao,