Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1256070 | Chinese Chemical Letters | 2009 | 4 Pages |
Abstract
Four new chiral 1,2,3,4-tetrahydroisoquinoline-derived β-amino alcohols were synthesized from commercially available l-DOPA. These ligands were evaluated in the asymmetric addition of diethylzinc to benzaldehydes and showed different catalytic activities (up to 86% ee). The solvent played an important role in the enantioselective process. The transition state models were proposed to explain the reversion of the product configuration.
Related Topics
Physical Sciences and Engineering
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Authors
Geng Xu, Zhan Zhu Liu,