Two new tetralone derivatives from the culture of Xylaria hypoxylon AT-028

Two new tetralone derivatives named xylariol A (1) and B (2) were isolated from the EtOAc extract of the culture broth of Xylaria hypoxylon AT-028 (Xylariaceae), and their structures were elucidated by MS, IR, 1D- and 2D-NMR spectra, and by X-ray diffraction analysis. 1 and 2 showed moderate cytotoxic activities against Hep G2 cells in the in vitro cytotoxic assay with IC50 values of 22.3 and 21.2 μg/mL, respectively.