Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1256170 | Chinese Chemical Letters | 2008 | 4 Pages |
Abstract
The interaction of the novel tetra-carboxylphenyl calix[4]arene (TCPC) with the bovine heart cytochrome c (Cc) was first investigated by fluorescence spectroscopy and molecular modeling methods. The formation of a stable 1:1 complex was monitored by fluorescence titration, and its binding constant is 1.916 × 107 L mol−1. Molecular modeling reveals the recognition mechanism of TCPC to the Cc surface, that is, the electrostatic interaction drives TCPC to the Cc surface, and the van der Waals interaction orientates TCPC parallel to the cleft of Cc.
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Authors
Wen Ting An, Yong Jiao, Xiao Hua Sun, Chuan Dong, Shao Min Shuang, Ping Fang Xia, Man Shing Wong,