Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1256187 | Chinese Chemical Letters | 2009 | 4 Pages |
Abstract
Mycobacterium tuberculosis FabH, an essential enzyme in mycolic acids biosynthetic pathway, is an attractive target for novel anti-tuberculosis agents. Structure-based design, synthesis of novel inhibitors of mtFabH was reported in this paper. A novel scaffold structure was designed, and 12 candidate compounds that displayed favorable binding with the active site were identified and synthesized.
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Authors
Xue Hui Zhang, Hong Yu, Wu Zhong, Li Li Wang, Song Li,