Article ID Journal Published Year Pages File Type
1256187 Chinese Chemical Letters 2009 4 Pages PDF
Abstract

Mycobacterium tuberculosis FabH, an essential enzyme in mycolic acids biosynthetic pathway, is an attractive target for novel anti-tuberculosis agents. Structure-based design, synthesis of novel inhibitors of mtFabH was reported in this paper. A novel scaffold structure was designed, and 12 candidate compounds that displayed favorable binding with the active site were identified and synthesized.

Related Topics
Physical Sciences and Engineering Chemistry Chemistry (General)
Authors
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