| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1256211 | Chinese Chemical Letters | 2009 | 4 Pages |
Abstract
DTPA and its two derivatives were synthesized and used as catalysts in DNA cleavage. Under physiological conditions, a series of experiments have been done. The effects of DNA cleavage with three ligands were studied under different concentrations, cleavage time, and pH values. The results strongly suggested that the plasmid DNA (pUC 19) can be cleaved efficiently by CITC-DTPA. For the cleavage reaction catalyzed by CITC-DTPA, Form I DNA could convert to Form II mostly, and the DNA-cleavage mechanism involved an oxidative pathway.
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Physical Sciences and Engineering
Chemistry
Chemistry (General)
Authors
Zhong Wei Yao, Jun Xu, Da Wei Zhang, Hong Hui Lin, Chuan Qin Xia,