| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1256495 | Chinese Chemical Letters | 2008 | 4 Pages |
Abstract
N-(2-Hydroxypropyl) methacrylamide copolymer-5-fluorouracil (PHPMA-FU) conjugates were synthesized by a novel and simplified synthetic route, and characterized by UV, FTIR and HPLC analyses. The conjugated content of 5-fluorouracil (5-FU) was 3.41 ± 0.07 wt%. The stabilities of PHPMA-FU conjugates under different conditions were studied. The results showed that HPMA copolymer was a potential carrier for tumor-targeting delivery of 5-FU.
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Authors
Fang Yuan, Fu Chen, Qing Yu Xiang, Xuan Qin, Zhi Rong Zhang, Yuan Huang,